An Overall View Of Bio Ethics Practices In Our Day To Day Life And It`S Remedies.

Abstract: Historically, ethics has been considered the province of religion i.e moral theology and large, still remains so. In most cases religion provides an important answer to the question, why one should act ethically. The ancient Greeks were the first to examine ethics philosophically and thus independently to religion . The major proponents of it were Socrates, Plato and Aristotle in the 5th & 4th centuries B.C. Now a days we can see lack of ethics everywhere of our life. This article try to find out –where & what are the ethics we are lacking behind in our day to days life and it`s probable remidies. Morality should be practiced and should start from the –“DINNING TABLE”. Beside this Government should pass down policies, which will facilitate this practice to get good citizens. The main thrust of modern ethics or moral philosophy is to attempt to lay the foundations of ethical conduct, which should be bear in mind with good faith.

Tumour necrosis factor-alpha as a new therapeutic target for rheumatoid arthritis: an update.

In rheumatoid arthritis (RA), the conventional therapies (first-line, second-line, third-line drugs) provide more or less effective symptomatic relief for a decade or so from the onset of the disease. However, the chronic inflammatory destructive processes involving connective tissue, cartilage and bone with their attendant disability progress relentlessly in majority of patients. Secondly, use of 'second-line' and 'third-line' drugs in RA are limited due to their side effects. Studies in animals and RA patients have confirmed that tumour necrosis factor-alpha (TNFalpha), an inflammatory cytokine, is of major importance in the rheumatoid disease process and thus, it might be an effective therapeutic target in RA. Animal model experiments and clinical trials were conducted with anti-TNFalpha monoclonal antibody (anti-TNFalpha MoAb) in RA recently. This anti-TNFalpha MoAb therapy was found to be both effective and safe which documented the coming-of-age of cytokine-based immunointervention in RA. Researchers are optimistic that modern medicine would certainly witness the application of this noble immunotherapy enabling to selectively target cytokines, e.g. TNFalpha, in RA as well as in other inflammatory autoimmune diseases in the near future.

Efficacy of aqueous extract of garlic & allicin in experimental shigellosis in rabbits.

The aqueous extract of garlic (Allium sativum) and allicin both showed significant in vitro antibacterial activity against isolates of multiple drug-resistant Shigella dysenteriae 1, Sh. flexneri Y, Sh. sonnei and enterotoxigenic Escherichia coli. The minimum inhibitory concentrations of the aqueous extract and allicin against Sh. flexneri Y were 5 and 0.4 microliters/ml, respectively. The two agents also showed promising in vivo antibacterial activity against Sh. flexneri Y when tested in the rabbit model of experimental shigellosis, fully curing the infected rabbits within 3 days. On the contrary, 4 of the 5 rabbits in the control group died within 48 h. The rectal swab of rabbits of the experimental groups became free of the challenge bacteria on the second day of treatment. The antibacterial activity against the challenge strain was observed in the sera of the treated rabbits with 30-60 min of administration of the agents. The LD50 values of the aqueous extract and allicin in mice were 173.78 ml/kg and 204.17 microliters/kg of body weight, respectively. At the therapeutic dose, the two agents did not show any adverse effects on the standard biochemical profile of blood.